Description

Buy SNAP-8 10mg Online

For laboratories and research institutions investigating SNARE complex dynamics, synaptic signalling mechanisms, and vesicular exocytosis pathways, our SNAP-8 10mg delivers verified ≥98% HPLC purity with full mass spectrometry confirmation. This synthetic octapeptide—derived from the N-terminal domain of SNAP-25 (synaptosomal-associated protein of 25 kDa)—is manufactured under stringent controlled conditions, vacuum-sealed in lyophilised form, and preserved through our temperature-monitored cold-chain. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays and temperature excursions that compromise research integrity. Every batch is accompanied by a comprehensive Certificate of Analysis, ensuring complete experimental traceability.

Research Applications & Key Benefits

• SNARE Complex Interaction Studies: SNAP-8 is designed to mimic the N-terminal end of SNAP-25, competing with the endogenous protein for a position within the SNARE (Soluble NSF Attachment Protein Receptor) complex. This competitive inhibition disrupts the formation of the four-helix bundle essential for membrane fusion, making it a valuable molecular probe for studying SNARE-mediated vesicular dynamics.

• Vesicular Exocytosis Research: In vitro assays demonstrate that SNAP-8 reduces catecholamine release from chromaffin cells in a dose-dependent manner, confirming its ability to inhibit vesicular exocytosis. At 500 µM, SNAP-8 achieves approximately 73% inhibition of stimulated catecholamine release, exceeding the maximal inhibition observed with the hexapeptide Argireline (approximately 60% at equivalent concentrations).

• Neurotransmitter Release Modulation: The octapeptide inhibits SNARE-complex-mediated neurotransmitter release, including acetylcholine, by forming an unstable, non-functional SNARE-like intermediate. This reversible inhibition provides a controlled mechanism for studying neuromodulatory pathways without inducing cellular toxicity.

• Comparative Peptide Structure–Activity Research: As an elongation of Argireline (Acetyl Hexapeptide-8) with two additional N-terminal amino acids (Glu-Met), SNAP-8 offers enhanced binding affinity and stability. At 200 µM, SNAP-8 inhibits catecholamine release by approximately 55% compared to approximately 40% for Argireline, representing a roughly 1.4-fold improvement in potency.

• In Vitro Cosmetic Peptide Research: Frequently used in laboratory studies investigating peptide-mediated signalling mechanisms and comparative activity of topical peptide actives, with observed effects dependent on experimental design, concentration, and model system.

• Reference Standard Applications: Suitable for use as a reference standard in peptide research, formulation stability studies, and quality control analytical method development.

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt.

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms, mass spectrometry data, and purity verification documentation available. Independent third-party testing confirms ≥98% purity standards.

Cold-Chain Integrity
Temperature-controlled storage at 2°C–8°C prior to dispatch, with insulated packaging designed to maintain lyophilised product stability during transit. Long-term storage recommended at -20°C for extended stability.

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.