Description

Buy N-Acetyl Selank Amidate 10mg Online 

For laboratories and research institutions investigating neurobiological mechanisms, GABAergic signalling, cognitive pathway modulation, and peptide stability optimization, our N-Acetyl Selank Amidate 10mg delivers verified ≥98% HPLC purity with full analytical testing. This synthetic heptapeptide, sequence Ac-Thru-Lys-Pro-Arg-Pro-Gly-Pro-NH₂, represents a chemically stabilized derivative of the parent compound Slank—a synthetic analogue of the human tetrapeptide tufts in developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. The N-terminal acetylation and C-terminal amination confer enhanced resistance to exa- and endopeptidases, extending stability in laboratory conditions compared to unmodified Slank. Manufactured under stringent controlled conditions, vacuum-sealed in lyophilized form, and preserved through our temperature-monitored cold-chain, every batch is accompanied by a comprehensive Certificate of Analysis. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays that compromise research integrity.

Research Applications & Key Benefits

• GABAergic Signalling Investigations: N-Acetyl Selank Amidate functions as an allosteric modulator of GABA-A receptors, increasing receptor sensitivity to endogenous GABA without directly activating the receptor—a mechanism distinct from benzodiazepines. Research applications include examining GABAergic neurotransmission, receptor binding kinetics, and anxiolytic pathway mechanisms in in vitro models.

• Enkephalin System Modulation: The peptide inhibits enkephalinase (neprilysin) and other endopeptidases responsible for endogenous enkephalin degradation, prolonging the half-life of Met-enkephalin and Leu-enkephalin. This makes it a valuable molecular probe for studying endogenous opioid peptide signalling pathways.

• Neurotrophic Factor & Cognitive Pathway Research: Studies have demonstrated modulation of BDNF mRNA expression in the hippocampus, supporting research into neuroplasticity, synaptic strengthening, and cognitive function mechanisms. The peptide also influences NGF expression and downstream signalling pathways.

• Monoamine System Research: N-Acetyl Selank Amidate stabilises dopamine, norepinephrine, and serotonin turnover in the prefrontal cortex, with effects on 5-HT₁A receptor sensitivity and gene expression involved in serotonin synthesis and transport. This supports investigations into neurotransmitter regulation and stress-response pathways.

• Immunomodulatory Pathway Studies: As a synthetic analogue of tuftsin, research examines its influence on cytokine expression (IL-6, IL-10, TNF-α), NK cell activity, and T-helper cell balance (Th1/Th2).

• Enhanced Stability Research: The N-acetyl and C-amide modifications provide significantly improved resistance to enzymatic degradation compared to unmodified Selank, making this peptide valuable for stability and bioavailability studies in peptide engineering research.

• Gene Expression Modulation: Microarray studies have shown Selank influences the expression of over 2,000 genes, with significant effects on inflammation, immune response, neurotransmitter signalling, apoptosis regulation, and oxidative stress response pathways.

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt.

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms and purity verification documentation available. Independent third-party testing confirms identity and purity standards. Typical batch purity exceeds 98%.

Cold-Chain Integrity
Temperature-controlled storage at 2°C–8°C (short term) or -20°C (long term) prior to dispatch, with insulated packaging designed to maintain lyophilized product stability during transit.

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes 

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.