Description

Buy Fragment 176-191 2mg Online UK

For laboratories and research institutions investigating growth hormone fragment-specific signaling pathways, our Fragment 176-191 2mg delivers verified ≥98% HPLC purity with full mass spectrometry confirmation. This synthetic 16-amino acid peptide corresponds to the C-terminal region (residues 176–191) of human growth hormone, featuring a disapplied bridge between Cys7 and Cys14 that confers structural stability. Manufactured under stringent controlled conditions and vacuum-sealed in lyophilized form, every batch is preserved through our temperature-monitored cold-chain from UK warehouse to your laboratory bench. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate the customs delays and temperature excursions that compromise research integrity. Every batch is accompanied by a comprehensive Certificate of Analysis from UKAS-accredited laboratories, ensuring complete experimental traceability.

Research Applications & Key Benefits

• Growth Hormone Fragment-Specific Signalling Research: Unlike full-length HGH, Fragment 176-191 does not directly activate the growth hormone receptor, nor does it stimulate IGF-1 secretion, making it a valuable molecular tool for investigating domain-specific peptide behaviour independent of classical GH receptor activation.

• Lipolysis & Lipid Metabolism Studies: In biochemical and cellular research models, this fragment has been studied for its influence on pathways associated with lipolysis (fat breakdown) and inhibition of lipogenesis (fat formation) via β3-adrenergic receptor signalling, without the broad hormonal effects associated with full-length HGH.

• Metabolic Pathway Investigation: Explored as a research tool for studying obesity models, metabolic regulation, energy expenditure, and mitochondrial activity pathways—with evidence suggesting effects on fat metabolism that avoid hyperglycemia linked to native HGH.

• Receptor-Independent Signalling Research: Used in in vitro studies examining structure-function relationships of GH-derived peptides, including fragment-specific binding characteristics and intracellular signalling responses distinct from intact hGH.

• Cancer Research Applications: Investigated in experimental models for its potential to enhance the cytotoxicity of chemotherapeutic agents such as doxorubicin when delivered via nanoparticle systems.

• Structural Stability & Bioactivity: The disapplied bridge between Cys7 and Cys14 forms a constrained cyclic core that is more resistant to enzymatic degradation than linear fragments, making this peptide suitable for extended in vitro assay protocols.

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt.

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms, mass spectrometry data, and purity verification documentation available. Our testing is conducted at UKAS & ISO 9001 accredited laboratories, not self-reported or generic COAs.

Cold-Chain Integrity
Temperature-controlled storage at 2°C–8°C prior to dispatch, with temperature-shielded packaging designed to maintain lyophilized product stability during transit. Long-term storage recommended at -20°C or below for extended stability.

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.