Description

Buy Premium Mod-GRF 5 mg (Modified GRF (1-29) / CJC-1295 without DAC) Online UK 

For laboratories and research institutions investigating growth hormone axis signalling, pulsatile secretion dynamics, and GHRH receptor pharmacology, our Premium Modified GRF (1-29) 5mg delivers verified ≥98% HPLC purity with full mass spectrometry confirmation. This synthetic 29-amino-acid GHRH analogue—widely referenced as CJC-1295 without DAC—incorporates four strategic amino acid substitutions at positions 2, 8, 15, and 27 that confer resistance to DPP-IV enzymatic degradation compared to native GHRH. Manufactured under stringent controlled conditions, vacuum-sealed in lyophilised form, and preserved through our temperature-monitored cold-chain, every batch is accompanied by a comprehensive Certificate of Analysis. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays and temperature excursions that compromise research integrity.

Research Applications & Key Benefits

• GHRH Receptor Signalling Studies: Modified GRF (1-29) activates the GHRH receptor on pituitary somatotrophs, stimulating growth hormone secretion via the cAMP/PKA signalling pathway. The tetrasubstituted backbone (D-Ala², Gln⁸, Ala¹⁵, Leu²⁷) enhances stability while maintaining full receptor bioactivity, making it a valuable molecular probe for receptor binding investigations.

• Pulsatile GH Release Modelling: Unlike DAC-conjugated variants, this non-albumin-binding formulation demonstrates an approximate 30-minute half-life that more closely approximates endogenous GHRH-mediated pulsatile secretion dynamics. This pharmacokinetic profile preserves the natural secretory rhythm and feedback loop—critical for research examining physiological GH pulse amplitude and frequency.

• Synergistic Pathway Studies: Frequently investigated alongside GHS-R agonists such as Ipamorelin or GHRP-2, where the combination of GHRH-R and GHS-R activation produces synergistic GH release greater than either pathway alone. This dual-pathway approach is central to understanding somatotroph regulation.

• Endocrine Axis & Metabolic Pathway Research: Used in in vitro studies examining growth hormone axis regulation, IGF-1 signalling dynamics, somatostatin feedback mechanisms, and metabolic pathway investigations including lipid oxidation and glucose homeostasis models.

• Circadian Rhythm & Sleep Research: Investigated in laboratory models examining the impact of amplified GH pulses on slow-wave sleep architecture and recovery cycles, reflecting the natural circadian rhythm of GH secretion.

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt.

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms, mass spectrometry data, and purity verification documentation available. Independent third-party testing confirms identity and purity standards.

Cold-Chain Integrity
Temperature-controlled storage at 2°C–8°C prior to dispatch, with insulated packaging designed to maintain lyophilised product stability during transit. Long-term storage recommended at -20°C for extended stability.

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation. No compound names appear on external packaging.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.