Description

Buy LL-37 5mg Online UK

For laboratories and research institutions investigating innate immune mechanisms, host-defence peptide signalling, and antimicrobial resistance models, our LL-37 5mg delivers verified ≥98% HPLC purity with comprehensive analytical testing . This synthetic 37-amino-acid peptide—the only cathelicidin-derived antimicrobial peptide identified in humans—is derived from the C-terminal domain of hCAP-18 and exhibits broad-spectrum antimicrobial activity against bacteria, fungi, and viruses . Manufactured under stringent controlled conditions, vacuum-sealed in lyophilised form, and preserved through our temperature-monitored cold-chain, every batch is accompanied by a comprehensive Certificate of Analysis. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays that compromise research integrity .

Research Applications & Key Benefits

• Antimicrobial Research & Drug Development: LL-37 demonstrates broad-spectrum activity against over 38 bacteria, 16 fungi, and 16 viruses through multiple mechanisms including membrane disruption, oxidative stress induction, cell cycle arrest, and biofilm suppression . Research applications include studying antimicrobial peptide–membrane interactions and developing next-generation therapeutics against multidrug-resistant pathogens such as MRSA, VRE, and resistant Klebsiella .

• Host-Defence & Innate Immune Signalling: As a multifunctional host defence peptide, LL-37 modulates immune signalling pathways, regulates inflammatory mediator release, and neutralises lipopolysaccharides from Gram-negative bacteria . It is widely used as a molecular tool to investigate cathelicidin biology and innate immune defence mechanisms in experimental systems .

• Immunomodulatory & Cytokine Research: LL-37 has been shown to influence cytokine and chemokine release in in vitro cellular models, making it valuable for research examining inflammation regulation, autoimmune mechanisms, and immune cell migration and proliferation .

• Wound Healing & Epithelial Biology: Research has explored LL-37’s role in epithelial repair, wound healing processes, and host defence at sites of inflammation and tissue injury . Studies examine its effects on keratinocyte and epithelial cell responses in tissue repair models.

• Cancer & Skin Biology Research: LL-37 has been investigated in cancer research models, particularly in relation to skin tumorigenesis and tumour microenvironment interactions. Expression studies examine LL-37’s presence in various cancers and its potential role in tumour biology .

• Structure–Activity & Peptide Engineering: The peptide exhibits structural versatility with mono-, di-, and tetrameric forms supporting its function and stability . LL-37 serves as a reference compound for structure–activity studies and the development of peptide-based antimicrobial and immunomodulatory analogues .

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt .

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms and purity verification documentation available. Typical batch purity exceeds 98% . Independent testing confirms identity and standards.

Cold-Chain Integrity
Temperature-controlled storage at 2°C–8°C prior to dispatch, with insulated packaging designed to maintain lyophilised product stability during transit. Long-term storage recommended at -20°C in desiccated, dark conditions .

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes 

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment 

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.