Description

Buy Kisspeptin – 5mg Online UK

For laboratories and research institutions investigating reproductive endocrinology, G-protein coupled receptor (GPCR) signalling, and neuroendocrine pathways, our Kisspeptin-10 5mg delivers verified ≥98% HPLC purity with comprehensive analytical testing. This synthetic decapeptide—also known as Metastin (45-54)—corresponds to the bioactive C-terminal fragment of the metastasis suppressor gene product KiSS-1 and acts as a potent agonist of the kisspeptin receptor (KISS1R / GPR54) with high binding affinity (Ki values of 0.042–2.33 nM depending on species). Manufactured under stringent controlled conditions, vacuum-sealed in lyophilised form, and preserved through our temperature-monitored cold-chain, every batch is accompanied by a comprehensive Certificate of Analysis. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays that compromise research integrity.

Research Applications & Key Benefits

• GnRH Neuron Regulation & Reproductive Endocrinology: Kisspeptin-10 acts as the primary upstream regulator of gonadotropin-releasing hormone (GnRH) neurons, playing a critical role in the hypothalamic-pituitary-gonadal axis. Research applications include investigating the mechanisms controlling puberty onset, reproductive function, and GnRH pulsatile secretion in in vitro models.

• GPCR Signalling & Receptor Pharmacology: Kisspeptin-10 induces calcium mobilization in cells expressing human and rat kisspeptin receptors (EC₅₀ = 0.18–1.1 nM) and stimulates arachidonic acid release in a concentration-dependent manner. It serves as a valuable molecular tool for studying Gq/11-coupled receptor signalling, receptor binding kinetics, and downstream intracellular cascades.

• Metastasis & Tumour Research: As a product of the metastasis suppressor gene KISS1, kisspeptin has been shown to inhibit metastasis and invasion in research models. Studies examine its anti-angiogenic effects, including concentration-dependent inhibition of HUVEC proliferation and migration, supporting cancer biology and metastasis research.

• Metabolic & Endocrine Research: Kisspeptin-54 (the full-length form) has been shown to inhibit insulin secretion from isolated mouse pancreatic β-cells under specific glucose conditions. Shorter fragments such as Kisspeptin-10 are used to investigate structure–function relationships and the role of kisspeptin signalling in metabolic regulation, including ovarian function and placental angiogenesis.

• Behavioural Neuroscience & Clinical Research: Recent clinical investigations have explored kisspeptin’s effects on neural processing and sexual behaviour, with studies demonstrating modulation of brain activity in key structures of the sexual-processing network and significant increases in penile tumescence in response to sexual stimuli. This supports laboratory research into the neurobiological mechanisms underlying reproductive behaviour.

• Structure–Activity Studies: As the minimal bioactive C-terminal fragment of the kisspeptin family, Kisspeptin-10 serves as a reference compound for structure–activity relationship studies, peptide engineering, and investigations of kisspeptin receptor ligand interactions.

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt.

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms and purity verification documentation available. Independent third-party testing confirms identity and purity standards.

Cold-Chain Integrity
Temperature-controlled storage at -20°C prior to dispatch, with insulated packaging designed to maintain lyophilised product stability during transit. Long-term storage recommended at -20°C in desiccated, dark conditions.

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.