Description

Buy Adipotide (FTPP) 5mg | High-Purity Research Peptidomimetic Oline UK

For laboratories and research institutions investigating vascular-targeted apoptosis, adipose tissue biology, and prohibition-mediated signaling, our Adipotide (FTPP) 5mg delivers verified ≥98% HPLC purity with comprehensive analytical testing. This synthetic chimeric peptidomimetic—also known as FTPP (Fat-Targeted Proapoptotic Peptide) or prohibit in-targeting peptide 1—comprises a cyclic homing domain that binds to prohibitin/Annexin A2 receptors on adipose vasculature and a proapoptotic domain that disrupts mitochondrial membranes upon internalisation . Manufactured under stringent controlled conditions, vacuum-sealed in lyophilized form, and preserved through our temperature-monitored cold-chain, every batch is accompanied by a comprehensive Certificate of Analysis. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays that compromise research integrity.

Research Applications & Key Benefits

• Vascular-Targeted Apoptosis Research: Adipotide is a bifunctional peptidomimetic designed to induce apoptosis in the vasculature of white adipose tissue selectively . The homing domain (CKGGRAKDC) recognises and binds to prohibitin and Annexin A2—proteins differentially expressed on the surface of endothelial cells in white adipose tissue vasculature . Once bound, the compound undergoes receptor-mediated endocytosis, delivering the proapoptotic domain to the intracellular compartment .

• Prohibitin Receptor Studies: The CKGGRAKDC motif binds to a receptor complex on adipose vasculature endothelium comprising prohibitin and Annexin A2 (ANXA2) . Prohibitin, a multifunctional protein involved in mitochondrial function, cell cycle regulation, and apoptosis, is overexpressed in certain cancer types and serves as a research target for vascular biology studies .

• Mitochondrial Membrane Disruption Research: The C-terminal effector domain—D(KLAKLAK)₂ synthesised using D-amino acids—adopts an alpha-helical conformation that interacts with mitochondrial membranes . This amphipathic domain inserts into lipid bilayers, with the hydrophobic face embedding in the membrane and charged lysine residues remaining exposed. This insertion disrupts mitochondrial membrane integrity, leading to loss of membrane potential, cytochrome c release, and activation of the intrinsic apoptotic cascade . The use of D-amino acids provides resistance to proteolytic degradation, extending the functional lifetime of the proapoptotic domain .

• Adipose Tissue Biology & Metabolic Research: Investigations suggest Adipotide exposure in research models may result in significant reductions in subcutaneous and visceral fat depots . The peptide’s specificity for white adipose tissue vasculature—without apparent effect on brown adipose tissue—has made it a valuable tool for dissecting the differential roles of fat subtypes in energy homeostasis.

• Angiogenesis & Vascular Biology: The concept of selectively inducing apoptosis in endothelial cells through ligand-directed delivery of proapoptotic sequences has broader implications for angiogenesis and vascular biology research. Prohibitin, one of the primary targets of Adipotide, has been implicated in various cancers, including breast, prostate, and ovarian malignancies.

Structural Components

• Homing Domain: CKGGRAKDC (9 amino acids, cyclic via disulfide bond between terminal cysteines) – binds to prohibitin/Annexin A2 on adipose vascular endothelium 

• Linker Region: Gly-Gly – flexible spacer connecting domains 

• Proapoptotic Domain: D(KLAKLAK)₂ (14 D-amino acids) – alpha-helical mitochondrial membrane disruptor 

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory .

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt .

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms and purity verification documentation available. Typical batch purity exceeds 98% (often >99.1% HPLC-verified), with COAs provided for verification and traceability .

Cold-Chain Integrity
Temperature-controlled storage at -20°C prior to dispatch, with temperature-shielded packaging designed to maintain lyophilised product stability during transit. Long-term storage recommended at -20°C, minimising freeze-thaw cycles.

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes 

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment 

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.