Description

Buy Modified GRF (1-29) 2mg (CJC-1295 without DAC) Online UK

For laboratories and research institutions investigating growth hormone axis signaling, our Modified GRF (1-29) 2mg delivers verified ≥98% HPLC purity with full mass spectrometry confirmation. This tetrasubstituted 29-amino-acid GHRH analogue—commonly referenced as CJC-1295 without DAC—features four strategic amino acid substitutions (positions 2, 8, 15, and 27) that confer enhanced resistance to DPP-IV enzymatic degradation compared to native GHRH (1-29) . Manufactured under stringent controlled conditions, vacuum-sealed in lyophilized form, and preserved through our temperature-monitored cold-chain, every batch is accompanied by a comprehensive Certificate of Analysis. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays and temperature excursions that compromise research integrity.

Research Applications & Key Benefits

• GHRH Receptor Signaling Studies: This tetrasubstituted GRF (1-29) analogue with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively exhibits enhanced resistance to DPP-IV enzymatic degradation compared to native GHRH, making it a valuable molecular probe for receptor binding, Gs/adenylate cyclase activation, and cAMP/PKA signalling pathway investigations.

• Pulsatile GH Secretion Modelling: Unlike DAC-conjugated variants, this non-albumin-binding formulation demonstrates a shorter effective half-life (~30 minutes) that more closely approximates endogenous GHRH-mediated pulsatile secretion dynamics—critical for research examining physiological GH pulse amplitude, frequency, and somatotroph biology.

• Endocrine Axis & Metabolic Pathway Research: Used in cellular assays investigating growth hormone axis regulation, IGF-1 signalling, somatostatin feedback dynamics, and metabolic pathway research including lipid oxidation and glucose homeostasis models.

• Dual-Receptor Pathway Investigation: Frequently studied alongside growth hormone secretagogues such as Ipamorelin to examine convergent versus independent receptor signalling pathways (GHRHR vs GHS-R1a) on somatotroph cell populations.

• Structural Stability & Bioactivity: The tetrasubstituted GRF backbone confers enhanced in vitro stability while retaining full GHRH receptor bioactivity—confirmed through cultured rat anterior pituitary cell assays demonstrating maintained GH secretion activity.

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt .

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms, mass spectrometry data, and purity verification documentation available. Independent third-party testing confirms identity and purity standards .

Cold-Chain Integrity
Temperature-controlled storage at 2°C–8°C prior to dispatch, with insulated packaging designed to maintain lyophilised product stability during transit. Long-term storage recommended at -20°C for extended stability .

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation. No compound names appear on external packaging.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade chemical supplied exclusively for:

• In-vitro laboratory experimentation

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes 

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment 

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research chemicals. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.