Description

Buy IGF-1 Long R3 100mcg Online UK

For laboratories and research institutions investigating cellular proliferation, differentiation, and survival signaling pathways, our IGF-1 Long R3 100mcg delivers verified ≥98% HPLC purity with full mass spectrometry confirmation. This synthetic analog of human insulin-like growth factor-1 comprises the complete IGF-1 sequence with an arginine substitution at position 3 and a 13-amino-acid N-terminal peptide extension. The engineered modifications confer over 100-fold reduced affinity for IGF-binding proteins (IGFBPs), resulting in significantly enhanced biological potency in vitro compared to native IGF-1. Manufactured under stringent controlled conditions, vacuum-sealed in lyophilized form, and preserved through our temperature-monitored cold-chain, every batch is accompanied by a comprehensive Certificate of Analysis. With 100% domestic UK stockholding and same-day dispatch on orders placed before 2:00 PM GMT, we eliminate customs delays and temperature excursions that compromise research integrity.

Research Applications & Key Benefits

• Cell Proliferation & Survival Studies: IGF-1 Long R3 is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling, making it a valuable tool for investigating mitogenic and anti-apoptotic signalling cascades in a wide range of cell types, including muscle, bone, cartilage, and stem cells .

• Serum-Free Cell Culture Optimization: The analog has been specifically engineered for use in serum-free and low-serum mammalian cell culture systems to promote cell growth, survival, and recombinant protein expression in CHO, HEK 293, and other commercially relevant cell lines. Its reduced IGFBP binding means it remains bioavailable in culture conditions that would otherwise sequester native IGF-1.

• Stem Cell & Developmental Biology Research: IGF-1 is required for embryonic development and, in the absence of insulin, is necessary for the maintenance of human pluripotent stem cells. Long R3 IGF-1 has been studied in haematopoietic models, where together with IL-3 it stimulates differentiation and proliferation of myeloid cells and regulates lymphopoiesis.

• Receptor Binding & Signalling Investigations: The IGF-1 Long R3 analog is used in receptor binding assays to study IGF-1 receptor (IGF-IR) pharmacology, signalling pathway activation, and interactions with IGF-binding proteins. It is fully biologically active in cell proliferation assays, with ED50 values ranging from 0.3–1.5 ng/mL in MCF-7 cells and ≤2.0 ng/mL in FDC-P1 cells.

• Metabolic Pathway Research: Used in investigations examining the metabolic effects of IGF-1 signalling, including glucose homeostasis, lipid metabolism, and energy balance in cellular models. The analog’s enhanced stability makes it suitable for extended duration culture experiments.

The Pure Peptides UK Advantage

100% Domestic UK Stockholding
All inventory is warehoused within the United Kingdom, eliminating international shipping delays, customs clearance uncertainties, and extended transit times. Your order ships from our UK facility directly to your laboratory.

Same-Day Dispatch Commitment
Orders confirmed before 2:00 PM GMT are dispatched the same working day via tracked courier services, ensuring minimal time between order placement and receipt.

Batch-Specific Certificates of Analysis
Each vial is traceable to its production batch, with full HPLC chromatograms, mass spectrometry data, and purity verification documentation available. Independent third-party testing confirms identity and purity standards .

Cold-Chain Integrity
Temperature-controlled storage at -20°C to -80°C as recommended for long-term preservation of this lyophilised protein . Insulated packaging maintains temperature stability during transit.

Discreet & Secure Delivery
Plain, unbranded outer packaging protects your research privacy. All shipments are fully tracked with delivery confirmation. No compound names appear on external packaging.

Dedicated UK Support
Our UK-based technical support team is available to assist with product queries, storage guidance, and reconstitution protocols. No dosing, administration, or clinical guidance is provided—we support your research objectives exclusively.

Regulatory Compliance & In-Vitro Disclaimer

FOR IN-VITRO RESEARCH & LABORATORY USE ONLY

This product is a research-grade protein supplied exclusively for:

• In-vitro laboratory experimentation

• Cell culture and tissue engineering research

• Analytical testing and method development

• Biochemical assay and cellular model research

• Scientific study and educational purposes

STRICTLY NOT FOR:

• Human consumption, administration, or therapeutic application

• Veterinary use or animal experimentation outside licensed laboratory settings

• Diagnostic, treatment, or preventative medical purposes

• Any application outside a controlled laboratory environment

All users must comply with applicable UK and EU regulations governing the procurement, handling, and use of research-grade proteins and peptides. This product is not a medicinal product, dietary supplement, or foodstuff. No medical or therapeutic claims are made, expressed, or implied. Researchers are responsible for ensuring that their intended use complies with institutional ethics committees and relevant regulatory frameworks.