Description

Buy IGF1 (1-3) DES 1mg Online UK

For accredited UK institutions, university laboratories, and independent research scientists requiring premium-grade synthetic compounds, our IGF1 (1-3) DES 1mg represents the gold standard in research peptide quality. Each batch is rigorously verified at ≥98.0% purity via HPLC and Mass Spectrometry, ensuring sequence accuracy and structural integrity for reproducible experimental outcomes. Manufactured under strict quality-controlled conditions, this compound undergoes vacuum-sealed lyophilisation to maintain stability during storage and is preserved through our cold-chain logistics network. With 100% domestic UK warehousing, we guarantee same-day dispatch (before 2:00 PM GMT) and next-working-day delivery, eliminating customs delays and temperature excursion risks associated with international sourcing. At £29.95 per single vial with discounted 5-vial packs available, we deliver exceptional value without compromising analytical-grade standards. buy igf1 des uk

Research Applications & Key Benefits

Biochemical Mechanism & Structural Profile

IGF1 (1-3) DES (Des(1-3) Insulin-like Growth Factor-1) is a 67-amino acid analogue of human IGF-1, specifically truncated by the removal of the N-terminal tripeptide Gly-Pro-Glu . This structural modification confers distinct research utility:

• IGFBP Evasion Mechanism: The truncation substantially reduces binding affinity to IGF-binding proteins (IGFBPs) that normally sequester native IGF-1 in biological systems. This property enables researchers to study IGF-1 receptor signalling with reduced confounding from binding protein interference .

• Receptor Binding Profile: Des(1-3)IGF-1 maintains high-affinity binding to the Type 1 IGF receptor, comparable to native IGF-1, while exhibiting negligible binding to the insulin receptor or Type 2 IGF receptor . This selectivity makes it an invaluable tool for receptor-specific pathway investigations.

• Enhanced Biological Activity: Research demonstrates that des(1-3)IGF-1 exhibits significantly greater potency than native IGF-1 in bioassays measuring protein synthesis stimulation. In rat L6 myoblast models, the half-maximal response concentration was 1.5 ng/ml for des(1-3)IGF-1 compared to 13 ng/ml for intact IGF-1 .

• Laboratory Research Utility:

  • Myogenic Cell Research: Investigate satellite cell activation, muscle cell proliferation, and differentiation pathway modelling .

  • IGFBP Biology: Study binding protein regulation and gene expression in muscle cell cultures .

  • PI3K/Akt/mTOR Pathway Analysis: Examine downstream signalling cascades involved in protein synthesis and cell growth.

  • Comparative Analogue Studies: Conduct structure-activity relationship research alongside IGF-1 LR3 and native IGF-1.

  • Tissue Repair Pathway Modelling: Explore cellular repair mechanisms and regenerative biology.

The Pure Peptides UK Advantage

Regulatory Compliance & In-Vitro Disclaimer

IMPORTANT NOTICE – FOR RESEARCH USE ONLY

This product is supplied strictly for in-vitro research, analytical testing, and laboratory study purposes only.

• Not for human or veterinary consumption. This compound is not a pharmaceutical, therapeutic agent, dietary supplement, or cosmetic ingredient.

• Not for administration to humans or animals. No claims are made regarding safety, efficacy, or biological effects in living organisms.

• Not intended to diagnose, treat, cure, or prevent any disease or medical condition .

• This peptide must only be handled by qualified professionals in appropriate laboratory environments following all relevant institutional, national, and international regulations and safety standards.

• The purchaser assumes full responsibility for compliance with all applicable laws and regulations governing the use, storage, and disposal of research chemicals.